Super Bowl 59 odds: 49ers are 2025 favorites to prevent a Chiefs championship three-peat

(AP Photo/Steve Luciano)

By: Ken Pomponio | Last updated: Feb. 12, 2024

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The Kansas City Chiefs are an official NFL dynasty with three Super Bowl titles in the last five seasons.

But, according to Super Bowl 59 odds posted by the leading online sportsbooks, the team that K.C. just vanquished Feb. 11 in Las Vegas -- the San Francisco 49ers -- is favored to block the Chiefs' 2024-25 run at the NFL's first Super Bowl three-peat.

Below, we take closer looks at the Chiefs' and 49ers' early 2024-25 season prospects as well as those for the other top favorites to win Super Bowl 59 on Feb. 9, 2025 in New Orleans.

View the current 2024-25 Super Bowl odds at top U.S. sports betting apps below plus more on the favorites to win Super Bowl 59. Click here to check out the latest Super Bowl bonuses & promos.

Super Bowl 59 favorites odds tracker

Team Current consensus odds Opening odds
San Francisco 49ers +550 +500
Kansas City Chiefs +675 +750
Baltimore Ravens +875 +850
Buffalo Bills +1000 +1200
Detroit Lions +1200 +1200

Who is most likely to win Super Bowl 59?

San Francisco 49ers ()

Coach Kyle Shanahan's Niners have been one of the league's elite teams over the last five seasons, making it to at least the NFC Championship in four out of the last five years.

But they don't have a Super Bowl win to show for it.

Quarterback Brock Purdy, who nearly outdueled Patrick Mahomes and the Chiefs in overtime in Super Bowl 58, will only be entering his third season next fall and he'll have the 2023 NFL Offensive Player of the Year in running back Christian McCaffrey back as a rather-helpful sidekick.

But some key players are either aging (All-Pro left tackle Trent Williams turns 36 in July), battling injuries (linebacker Dre Greenlaw ruptured his Achilles in the Super Bowl) or are pending free agents (defensive linemen Chase Young and Javon Kinlaw) and the team already is entering the offseason more than $3 million over the projected salary cap.

Kansas City Chiefs ()

The Chiefs on Feb. 11 became the league's first back-to-back Super Bowl champs in 19 years, and now they have their sights set on the NFL's first Big Game three-peat.

Mahomes, already a three-time Super Bowl champ and game MVP winner, is still a year away from his age-30 season and head coach Andy Reid looks to be staying put for the eight-time-defending AFC West champs.

If K.C. can find a way to retain stud free agent defensive tackle Chris Jones and bolster a sub-par wide receiver corps, the Chiefs will remain the league's team to beat -- as the odds-on Super Bowl favorite or not.

Baltimore Ravens ()

Baltimore boasted the NFL’s best 2023 record at 13-4 and the league’s MVP in QB Lamar Jackson.

But the pressure is mounting for Jackson, coach John Harbaugh and the Ravens, who haven't made it back to the Super Bowl since winning it all in 2012-13.

With the dual-threat Jackson still in his prime at 27 and one of the league's best defenses in 2023, the Ravens appear primed to be right in the mix.

However, getting back to even last season's level might be a tough ask considering the competition in the rugged AFC — including QB Joe Burrow’s return from injury for the division-rival Cincinnati Bengals — and the 22 unrestricted free agents the team has entering the offseason.

Buffalo Bills ()

The Bills have been perennial NFL contenders of late, but much like the Ravens, they don't have as much as a recent Super Bowl appearance to show for it.

Coach Sean McDermott’s Bills have won four straight AFC East titles and made the playoffs in six of the last seven seasons, but they’ve only made it as far as the AFC Championship only once during that span.

QB Josh Allen remains one of the league’s best, but it's become obvious that he's going to need some better supporting cast members to help lift Buffalo over the hump.

And that's going to be tough without some creative roster and financial juggling as the Bills are heading into the offseason more than a projected $50 million over the salary cap.

Detroit Lions ()

Coach Dan Campbell's Lions in 2023 notched the franchise’s first postseason win in 32 years and came up just three points short in the NFC title game of making Detroit’s first-ever Super Bowl appearance.

With a core of QB Jared Goff, wideout Amon-Ra St. Brown, defensive end Aidan Hutchinson and one of the league's top offensive lines, the Lions look to be in good shape entering the 2024-25 season.

And if Detroit can add a few more complementary pieces and shore up the league’s sixth-worst 2023 pass defense, that inaugural Big Game berth very well could come next February in the Big Easy.

Super Bowl 58 betting recap

Entering the 2023 season, both the Chiefs and 49ers were among the top five Big Game favorites, but thanks to a six-game win streak in the second half of the season, San Francisco seized the NFC's No. 1 seed and moved into the Super Bowl 58 favorite's role in late November. The Niners held that distinction up until kickoff.

Team Preseason Super Bowl odds Gametime moneyline odds
Kansas City Chiefs +600 +110
San Francisco 49ers +1000 -130

Initially, the 49ers opened as 2.5-point favorites at many sportsbooks, but despite strong public backing for Mahomes and the underdog Chiefs, the point spread only dipped slightly to Niners -2 by kickoff with sharp money coming in on San Francisco.

In the game itself, the 49ers jumped out to a 10-0 lead before the Chiefs took their first lead at 13-10 late in third quarter. Kansas City sent the game to overtime -- the second OT period in Super Bowl history -- with a 29-yard field goal that knotted the score 19-19 with 3 seconds remaining , and then prevailed by answering the Niners' opening-possession field goal with a 3-yard Mahomes-to-Mecole Hardman TD pass for a 25-22 final.

That was significant as the Super Bowl 58 game total opened at 47 points and had climbed to 47.5 before settling in at 46.5 at many sportsbooks just prior to kickoff.

It also marked the second straight season K.C. won as a Big Game underdogs as the Chiefs were catching 1.5 points on the Super Bowl 57 closing line to the Philadelphia Eagles. Kansas City prevailed 38-25.

Two years earlier in Super Bowl 55, the Chiefs closed as 3-point favorites against the Tampa Bay Buccaneers, but Tom Brady and Co. rolled to a 31-9 win in their home stadium.

In Super Bowl 54, Kansas City was favored by 1.5 points against the 49ers in Miami and rallied to win 31-20 after scoring 21 unanswered points in the fourth quarter.

Overall, Super Bowl underdogs are 16-7-1 ATS and 12-11 SU (including one pick 'em in 2014-15) since 2000.

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Ken Pomponio is a career sports journalist with more than 30 years of writing/editing experience for a variety of online and print outlets. The NFL is his first love, with primary interests in sports wagering and fantasy football.